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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T76830 |
Teneliximab
Chi220,Anti-Human CD40 Recombinant Antibody,BMS 224819 |
TNF | Apoptosis |
Teneliximab (Chi220) 是一种嵌合的单克隆抗体,也是一种肿瘤坏死因子受体超家族成员5(CD40)抑制剂,可阻断CD40-CD40L 的相互作用。Teneliximab 通过CD40 和外周B细胞损耗发挥部分激动剂活性,可用于研究器官移植排斥和类风湿关节炎。 | |||
T76825 | Ruplizumab | ||
Ruplizumab (BG 9588) 是一种人源化单克隆抗 CD40L(TNF Receptor) IgG1κ 抗体。Ruplizumab 具有用于系统性红斑狼疮疾病研究的潜力。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00170 |
CD40 Protein, Human, Recombinant (aa 21-193, His & Avi), Biotinylated
CD40 antigen, TNFRSF5,CD40 molecule,C... |
Human | HEK293 Cells |
CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects.CD40 molecule is a potential target for cancer immunotherapy. There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells. | |||
TMPJ-01420 |
CD40 Protein, Cynomolgus, Recombinant (hFc)
Tumor Necrosis Factor Receptor Superfamily member 5... |
Cynomolgus | HEK293 Cells |
CD40 Protein, Cynomolgus, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 48-70 KDa and the accession number is XP_005569275.1. | |||
TMPJ-00634 |
CD40 Protein, Cynomolgus, Recombinant (His)
CDw40,TNFRSF5,B-Cell Surface Antigen CD40,... |
Cynomolgus | HEK293 Cells |
CD40 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 28-30 KDa and the accession number is G7PG38. |